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Feverfew
(Tanacetum parthenium)


 General Info  

Active Forms


Absorption


Dietary Sources


 Dosage Info
Dosage Range
100-250mg (standardized extract), 1-3 times a day.

Fresh Leaf: 1 to 3 leaves (25 to 75 mg), 1-2 times daily has been recommended.(1, 2)

Most Common Dosage
250mg (standardized extract) daily.

Fresh Leaf: 1 leaf (25 mg), 1-2 times daily has been recommended.

Dosage Forms

Adult RDI


Adult ODA


 
 Overview
Interactions
Drug/Herb Interactions
Anticoagulant medications
Antiplatelet medications
Feverfew has gained immense popularity because of its prophylactic effectiveness in relieving migraine headaches.(3) It may take up to a month for therapeutic results to be seen. Once it is discontinued the effectiveness for migraine prevention dissipates. Feverfew is also used for inflammatory conditions such as rheumatoid arthritis,(4) relaxing smooth muscle in the uterus,(5) inhibiting platelet aggregation and blood clotting(6, 7) and fever.(8) The flowers from the plant have been used as a vermifuge. Feverfew has also been used as a natural insecticide.(9)
 Toxicities & Precautions
General
No toxicity has been seen in clinical trials in recommended doses.(10)

Abruptly discontinuing use may create a reflex response with migraines.(11)

Allergy
Do not use if allergic to pyrethrums. Use with caution in individuals with severe ragweed allergy or allergy to members of the daisy and chrysanthemum family (Compositae).(12)

Health Conditions
Based on pharmacology, use with caution in individuals with bleeding disorders.(13)

Pregnancy/Breast-Feeding
Based on pharmacology and animal studies, do not use if pregnant.(14)

Age Limitations
Do not use in children under 2 years of age unless recommended by a physician.

 Symptoms & Causes of Deficiency
 Footnotes
1 Johnson ES, et al. Efficacy of Feverfew as Prophylactic Treatment of Migraine. British Medical Journal. 1985;291:569-73.
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2 O'Hara M, Kiefer D, Farrell K, Kemper K. A review of 12 commonly used medicinal herbs. Arch Fam Med. Sep1998;7(6):523-536.
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3 Johnson ES, et al. Efficacy of Feverfew as Prophylactic Treatment of Migraine. British Medical Journal. 1985;291:569-73.
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4 Makheja AM, et al. The Active Principle in Feverfew. Lancet. 1981;2(8254):1054.
5 Groenewegen WA, et al. Amounts of Feverfew in Common Preparations of the Herb. Lancet. 1986; 1(8471):44-45.
6 Biggs MJ, et al. Platelet Aggregation in Patients Using Feverfew for Migraine. Lancet. 1982;2(8301):776.
7 Groenewegen WA, et al. A Comparison of the Effects of an Extract of Feverfew and Parthenolide, a Component of Feverfew, on Human Platelet Activity In-vitro. J Pharm Pharmacol. 1990;42(8):553-57.
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8 Sumner H, et al. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol. 1992;43(11):2313-20.
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9 Dreisbach RH. Handbook of Poisoning. 11th ed. CA: Lange Medical Publications; 1983:552.
10 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996:119-21.
11 PDR for Herbal Medicines, 2nd ed. Montvale, NJ: Medical Economics Company; 2000:307.
12 Schmidt RJ. Plant dermatitis. Compasitae. Clin Dermatol. Apr1986;4(2):46-61.
13 Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13): 1221-7.
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14 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996:119-21.
 
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